C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/56 (2006.01) G01N 33/00 (2006.01) G01N 33/48 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2605003
A method for obtaining a percent aggregation or inhibition of platelets resulting from anti-platelet using a single blood sample is achieved . An assay device is provided. The assay device has multiple channels, each coupled to a common introduction port. A first platelet activator is sensitive to activation pathway targeted by the anti-platelet drug. A second platelet activator is insensitive to the activation pathway targeted by the anti- platelet drug. An anti-coagulated sample is introduced simultaneously to the first and second channels. A level of platelet aggregation is simultaneously made in both channels.
L'invention concerne un procédé permettant d'obtenir un pourcentage d'agrégation ou d'inhibition plaquettaire provenant d'une antiplaquette au moyen d'un unique échantillon sanguin. L'invention concerne également un dispositif d'analyse comprenant de multiples canaux, chacun d'eux étant couplé à un orifice d'introduction commun. Un premier activateur de plaquette est sensible au parcours d'activation ciblé par le médicament antiplaquettaire. Un second activateur de plaquette est insensible au parcours d'activation ciblé par le médicament antiplaqettaire. Un échantillon anti-coagulé est introduit simultanément dans le premier et le second canaux. Un niveau d'agrégation de plaquettes est simultanément obtenu dans les deux canaux.
Durbin Dennis
Swaim Lisa
Accumetrics Inc.
Smart & Biggar
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