G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 21/64 (2006.01) G01N 21/27 (2006.01)
Patent
CA 2688440
Method for determining the content of a chromophoric and nonfluorescent compound, referred to as first compound, of a biological tissue (30) of a biological entity, wherein said biological tissue (30) also comprises a chromophoric and fluorescent compound, referred to as second compound, and wherein said method comprises at least one iteration of the following operations: emission, in the direction of said tissue (30), of a first, ~reference~, optical radiation and of a second, ~measuring~, optical radiation, each chosen so as to induce a fluorescence radiation from said second compound, wherein each of said first and second radiations is partially absorbed by said first compound, measurement of said fluorescence radiations induced by said first and second radiations, and determination, from said measurement, of the content of said first compound in said tissue; characterized in that said method also comprises at least one compensation for saturation of the measurement due to too great an absorption of the measuring radiation by said first compound, wherein said compensation comprises a choice, for said measuring radiation, of a wavelength corresponding to a weaker absorption in the absorption spectrum of the first compound.
Procédé pour déterminer la teneur en un composé chromophore et non fluorescent, dit premier composé, d'un tissu biologique (30) d'une entité biologique, ledit tissu biologique (30) comprenant en outre un composé chromophore et fluorescent, dit deuxième composé, ledit procédé comprenant au moins une itération des opérations suivantes; émission, en direction dudit tissu (30), d'un premier rayonnement optique, dit de référence, et d'un deuxième rayonnement optique, dit de mesure, chacun choisi de manière à induire un rayonnement de fluorescence dudit deuxième composé, chacun desdits premier et deuxième rayonnements étant partiellement absorbé par ledit premier composé, mesure desdits rayonnements de fluorescence induits par lesdits premier et deuxième rayonnements, et détermination, à partir de ladite mesure, de la teneur en ledit premier composé dudit tissu; caractérisé en ce que ledit procédé comprend en outre au moins une compensation d'une saturation de mesure due à une trop grande absorption du rayonnement de mesure par ledit premier composé, ladite compensation comprenant un choix, pour ledit rayonnement de mesure, d'une longueur d'onde correspondant à une plus faible absorption dans le spectre d'absorption du premier composé.
Cerovic Zoran
Goulas Yves
Latouche Gwendal
Moise Nicolae
Centre National de La Recherche Scientifique
Force-A
Smart & Biggar
Universite Paris Sud
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