Method and system for coating a surface of a medical device...

B - Operations – Transporting – 05 – D

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B05D 3/00 (2006.01) A61F 2/06 (2006.01) B05C 13/02 (2006.01) C23C 14/00 (2006.01)

Patent

CA 2697239

A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution- retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed.

L'invention concerne un dispositif médical revêtu de médicament multicouche tel que par exemple une endoprothèse vasculaire d'élution de médicament extensible qui est formée par des techniques de pulvérisation d'impulsion sous vide où chaque couche est irradiée pour améliorer les propriétés d'adhérence et/ou d'élution de médicament avant la formation des couches suivantes. Les couches peuvent être homogènes ou formées à partir de médicaments divers. Elles peuvent incorporer un matériau retardateur d'élution non polymère et alterner avec une ou plusieurs couches de matériaux retardateurs d'élution non polymères. Les liants et/ou matrices polymères ne sont pas utilisés dans la formation des revêtements, toutefois, les revêtements de médicament purs présentent de bonnes propriétés mécaniques et de vitesse d'élution. Des systèmes, des procédés et des articles de dispositif médical sont décrits.

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