G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2353110
The present invention provides a method and system for identifying, designing, and synthesizing proteins and protein backbones. The invention permits the qualitative identification of designable protein configurations and synthesis of protein folds. The method and system involve generating backbone protein configurations using a set of dihedral angle pairs, normalizing the total surface exposure of the configurations; generating a random set of sequences of hydrophobicities with uniform weight on the space of allowed sequences; determining, for each randomly generated sequence, which of the remaining configurations is the ground state; recording a ground-state configuration for each sequence wherein the desirable configurations are those containing the most sequences with that configuration as their ground state and finally, synthesizing sequences of amino acids for the desirable configurations.
Miller Jonathan
Tang Chao
Wingreen Ned S.
Zeng Chen
Nec Research Institute Inc.
Smart & Biggar
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