H - Electricity – 01 – J
Patent
H - Electricity
01
J
H01J 49/42 (2006.01) G01N 21/00 (2006.01) G01N 27/62 (2006.01) G01N 27/64 (2006.01) H01J 49/10 (2006.01) H01J 49/16 (2006.01)
Patent
CA 2477835
A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triplequadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple- reaction-monitoring (MRM) mode. Significantly improved measurement sensitivity is obtained by applying laser pulses to the ion source at a high pulse rate of about SOOHz or higher. This allows the data acquisition to be performed rapidly, and the speed of about one second for each sample point on the ion source target has been achieved.
L'invention porte sur une technique de quantification par spectrométrie de masse permettant de quantifier à haut rendement des petites molécules et utilisant une source d'ions à désorption laser (par exemple MALDI) reliée à un analyseur de masses à triple quadripôle. Les ions de la source sont amortis/refroidis par des collisions, puis analysés quantitativement par ledit analyseur fonctionnant en mode MRM (suivi de réactions multiples). On obtient ainsi une sensibilité de mesures significativement améliorée en appliquant à la source d'ions des impulsions laser de fréquence élevée (500 Hz ou plus), ainsi qu'une acquisition rapide des données, pouvant atteindre une vitesse d'environ une seconde pour chaque point échantillon de la cible de la source d'ions.
Chau Tung
Corr John J.
Covey Thomas R.
Fisher William H.
Chau Tung
Corr John J.
Covey Thomas R.
Dh Technologies Development Pte. Ltd.
Fisher William H.
LandOfFree
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