Method and system for optimizing dose delivery of radiation

A - Human Necessities – 61 – N

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A61N 5/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2587587

The invention relates to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams mapped so as to pass through the at least one non-target volume are limited such that the second term is zero only if the weights of beamlets passing through the at least one non- target volume are zero. This limit helps to avoid the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function using matrix inversion. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.

L'invention concerne des procédés et systèmes améliorés pour optimiser efficacement du point de vue computationnel l'administration dosée de rayonnements. Cette optimisation consiste à déterminer une forme améliorée de fonction objectif à utiliser pour le mappage de faisceaux de radiothérapie vers un volume corporel d'un patient, présentant au moins un volume cible et au moins un volume non cible. Cette fonction objectif présente un premier terme relatif audit volume cible et un second terme relatif audit volume non cible. Cette optimisation consiste également à déterminer un minimum pour cette fonction objectif, des faisceaux mappés de façon à pouvoir traverser ledit au moins un volume non cible étant limités, de sorte que le second terme est nul seulement si les poids de petits faisceaux traversant ledit volume non cible sont nuls. Cette limite permet d'éviter l'occurrence de poids de faisceaux négatifs, ce qui facilite la détermination computationnellement efficace du minimum de la fonction objectif utilisant l'inversion de matrice. Après cette optimisation, la radiothérapie est administrée sur la base du minimum déterminé pour la fonction objectif.

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