C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 39/21 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/115 (2006.01) C07K 14/16 (2006.01) G06F 17/00 (2006.01) G06F 17/30 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2444001
The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of spacer nucleic acid at the junctions of the multi-epitope constructs encoding a plurality of CTL and/or HTL eoutioe oeotudes so as to minimize the number of junciontal epitopes and provide vaccines with increased immunogenicity.
L'invention se rapporte au domaine de la biologie. Elle se rapporte en particulier à une méthode et à un système destinés à mettre au point des vaccins multi-épitopes optimisés présentant des combinaisons choisies d'acides nucléiques espaceurs aux jonctions des constructions multi-épitopes codant une pluralité de peptides d'épitopes des lymphocytes T cytotoxiques et/ou des lymphocytes T inducteurs, de façon à réduire au minimum le nombre d'épitopes jonctionnels et à fournir des vaccins présentant une antigénicité accrue.
Baker Denise Marie
Brown David H.
Chesnut Robert
Livingston Brian D.
Newman Mark J.
Epimmune Inc.
Mbm Intellectual Property Law Llp
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