Method and system for predicting therapeutic agent...

G - Physics – 06 – F

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G06F 19/18 (2011.01) G06N 3/08 (2006.01)

Patent

CA 2415832

A method and system for predicting the resistance of a disease to a therapeutic agent is provided. Further provided is a method and system for designing a therapeutic treatment agent for a patient afflicted with a disease. Specifically, the methods use a trained neural network to interpret genotypic information obtained from the disease. The trained neural network is trained using a database of known or determined genotypic mutations that are correlated with phenotypic therapeutic agent resistance. The present invention also provides methods and systems for predicting the probability of a patient developing a genetic disease. A trained neural network for making such predictions is also provided. Also provided is a method and system for determining the genetic basis of therapeutic agent resistance.

L'invention concerne un procédé et un système de prédiction de la résistance d'une maladie à un agent thérapeutique, ainsi qu'un procédé et un système de désignation d'un agent de traitement thérapeutique destiné à un patient souffrant d'une maladie. Ces procédés consistent notamment à utiliser un réseau neuronal, spécialisé, pour interpréter des informations génotypiques obtenues à partir de la maladie, à spécialiser le réseau neuronal au moyen d'une base de données de mutations génotypiques connues ou déterminées et corrélées à la résistance phénotypique à l'agent thérapeutique. L'invention concerne encore des procédés et systèmes de prédiction de la probabilité d'apparition d'une maladie génétique, chez un patient, de même que le réseau neuronal, spécialisé, servant à établir de telles prédictions. L'invention concerne enfin un procédé et un système de détermination de la base génétique de la résistance à un agent thérapeutique.

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