Method and system for providing bioactive agent release coating

Details Method and system for providing bioactive agent release coating Method and system for providing bioactive agent release coating

A - Human Necessities

61

L

A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2490241

A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

L'invention concerne une composition de revêtement et un procédé servant à l'application de cette compositions dans des conditions d'hygrométrie contrôlée. Ces compositions sont destinées à être utilisées pour recouvrir des surfaces de dispositifs afin de réguler et/ou d'augmenter leur capacité à libérer des agents bioactifs dans des systèmes aqueux. La composition de revêtement est tout particulièrement conçue pour être utilisée avec des dispositifs médicaux soumis à des flexions et/ou à des dilatations importantes lorsqu'ils sont déployés et/ou utilisés, tels que des stents et des cathéters. La composition contient l'agent bioactif combiné à un mélange renfermant un premier composant polymère, tel que du polyalyl(méth)acrylate, du polyaryl(méth)acrylate, du polyaralkyl(méth)acrylate, ou du polyaryloxyalkyl(méth)acrylate, et un second composant polymère, tel que du poly(éthylène-co-vinyle acétate).

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