Method and system for separation and purification of at...

C - Chemistry – Metallurgy – 07 – B

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C07B 63/00 (2006.01) B01D 15/08 (2006.01) B01D 15/20 (2006.01) B01D 15/32 (2006.01) C07D 489/00 (2006.01) C07D 489/02 (2006.01) C07G 5/00 (2006.01)

Patent

CA 2477739

An apparatus and method for separating at least one narcotic alkaloid that includes loading a stationary phase media into a high performance preparative liquid chromatography column, feeding a crude narcotic alkaloid solution into the chromatographic column, applying a mobile phase to the chromatographic column, and recovering a narcotic alkaloid eluate from the chromatographic column. The narcotic eluates are collected and treated separately from each other. Each separated alkaloid, however, has sufficient recovery and purity.

L'invention concerne un dispositif et un procédé destinés à séparer au moins un alcaloïde narcotique. Le procédé consiste à introduire un milieu à phase stationnaire dans une colonne de chromatographie liquide préparative haute performance, à acheminer une solution d'alcaloïde narcotique brute dans la colonne chromatographique, à appliquer une phase mobile sur la colonne chromatographique, puis à récupérer un éluat d'alcaloïde narcotique à partir de la colonne chromatographique. Les éluats narcotiques sont recueillis et traités séparément les uns des autres. Toutefois, chaque alcaloïde séparé présente une degré de récupération et de pureté suffisant.

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