Method and system for the controlled release of biologically...

Details Method and system for the controlled release of biologically... Method and system for the controlled release of biologically...

A - Human Necessities

61

M

167/162

A61M 31/00 (2006.01) A61K 38/28 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1168983

Method and System for the Controlled Release of Biologically Active Substances to a Body Fluid Abstract A process and system for controlled delivery of a biologically active substance to an animal body fluid which comprises contacting fluid with a reversible complex of a conjugate (1) and a binding ma- cromolecule (2), wherein the conjugate (1) comprises a biologically active portion which is intended to be proportionately released into a body fluid stream in response to varying concentration levels of a component of the body fluid stream, and a complexing substrate por- tion which conjugates with the biologically active portion and which is characterized by affinity to the binding macromolecule (2), compe- titively or non-competitively with the variable component of the body fluid; thereby causing the component present in the body fluid to complex to the binding macromolecule and thus releasing the conjugate (1) therefrom into the fluid. The process and system are particularly applicable for the glu- cose-controlled release of insulin and other hypoylycemic agents in the treatment of diabetes.

356872

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