Method and system to determine revised dosage

Details Method and system to determine revised dosage Method and system to determine revised dosage

G - Physics

06

F

G06F 19/00 (2011.01) A61K 39/00 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2455455

A method, system and apparatus for use in treating a patient receiving a biological substance, such as a cancer vaccine, to optimize therapy and prevent an adverse response. This system employs surrogate markers or indicators including blood levels of the vaccine to determine the next required dose for a patient. Since the surrogate markers may be employed as a percent change in status, virtually any indicator can be used. Surrogate markers could include any measure of the effectiveness of the vaccine's action. Given the effectiveness of the vaccine's action relative to the surrogate markers, a change in vaccine dose is calculated by the system. Conversely, by employing this system, one could determine the expected result of the vaccine dose change on the surrogate markers.

L'invention concerne un procédé, un système et un appareil destinés à être utilisés dans le traitement d'un patient recevant une substance biologique, telle qu'un vaccin anticancéreux, afin d'optimiser la thérapie et d'empêcher un effet secondaire. Ce système utilise des marqueurs de substitution ou des indicateurs de niveaux sanguins du vaccin afin de déterminer la prochaine dose nécessaire. Puisque le marqueur de substitution peut être utilisé en tant que changement centésimal d'état, il est possible d'utiliser virtuellement n'importe quel indicateur. Les marqueurs de substitution peuvent comprendre toute mesure de l'efficacité de l'action du vaccin. L'efficacité de l'action du vaccin étant connue par rapport à des marqueurs de substitution, le système calcule un changement de dose de vaccin. Inversement, l'utilisation de ce système permet de déterminer le résultat attendu du changement de dose de vaccin sur les marqueurs de substitution.

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