Method and systems for administering drugs transdermally...

A - Human Necessities – 61 – K

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A61K 47/26 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2098196

Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally adminis- tered pharmacologically active agents. The compositions contain a sorbitan ester in addition to the selected pharmacologically ac- tive agent and may also contain Cl-C4 aliphatic alcohol. Methods and drug delivery systems are provided which systems have a laminated matrix or a drug reservoir. In the drug reservoir type of Figure 1, designated (10) there is provided a backing layer (12), a drug reservoir (14) and a two piece release liner (16a) and (16b). In the laminated type, designated (18) in Fi- gure 2, there is provided a backing film (20), a reservoir (22), a ring shaped layer (24) of an adhesive, a membrane layer (26) and a sealable inner liner.

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