Method and topical formulation for treating skin conditions...

A - Human Necessities – 61 – K

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A61K 33/08 (2006.01) A61K 8/19 (2006.01) A61K 8/41 (2006.01) A61K 8/42 (2006.01) A61Q 17/04 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2464436

A composition and method are provided for alleviating the dermatological signs of intrinsic and extrinsic aging. A topical formulation containing a cosmeceutically active base, wherein the formulation provides a pH in the range of about 8.0 to 13.0 at the skin surface, is applied to the skin in order to prevent or treat aging-related skin conditions such as wrinkles, dry skin, age spots, sun damage (particularly UV radiation-induced oxidative stress), blemishes, hyperpigmented skin, age spots, increased skin thickness, loss of skin elasticity and collagen content, dry skin, lentigines and melasmas. The cosmeceutically active base is either an inorganic base, such as an inorganic hydroxide, an inorganic oxide, or a metal salt of a weak acid, or an organic base, particularly a nitrogenous base such as may be selected from primary amines, secondary amines, tertiary amines, amides, oximes, nitriles, aromatic and non-aromatic nitrogen-containing heterocycles, urea, and mixtures thereof.

L'invention concerne une composition et une méthode qui permettent d'atténuer les signes dermatologiques d'un vieillissement intrinsèque et extrinsèque. On applique sur la peau une formulation topique contenant une base active sur le plan cosméceutique et présentant un pH compris entre environ 8,0 et 13,0 au niveau de la surface cutanée afin de prévenir ou de traiter les maladies de la peau associées au vieillissement, notamment les rides, le dessèchement de la peau, les taches de vieillissement, les lésions dues au soleil (en particulier le stress oxydatif induit par les rayonnements ultraviolets), les lésions épidermiques, l'hyperpigmentation de la peau, l'épaississement de la peau, la perte de l'élasticité de la peau et la baisse du taux de collagène, la lentiginose et les mélasmes. Cette base active sur le plan cosméceutique est soit inorganique, telle qu'un hydroxyde inorganique, un oxyde inorganique ou un sel métallique d'un acide faible, soit organique, telle qu'une base azotée comme celle qui peut être sélectionnée pour les amines primaires, les amines secondaires, les amines tertiaires, les amides, les oximes, les nitriles, les hétérocycles aromatiques et non aromatiques contenant de l'azote, l'urée et des mélanges de ces éléments.

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