C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/54 (2006.01) A61K 38/16 (2006.01) A61K 38/47 (2006.01) A61P 1/14 (2006.01) C12Q 1/40 (2006.01) C12N 9/14 (2006.01) C12N 9/24 (2006.01) C12N 9/50 (2006.01)
Patent
CA 2636864
Physiological enzyme complex having active amylases, active lipases, and active proteases, of human (saliva or pancreatic enzymes), yeast, plant, fungi, and or microbial origin, preferably digestive enzyme complex such as, 4.alpha.D- glucan glucanohydrolase; Exo-1,4.alpha.glucosidase; Beta-fructofuranosidase; Protease (3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase, or digestive enzyme complex containing salivary like enzymes , gastric like proteins and enzymes, pancreatic like enzymes for the treatment of high levels / high excess of polysaccharides and disaccharides, correction, and treatment of amylases malfunctioning activity or amylases inactivity. Correction and treatment of high levels of saccharides in the body, in association with or without malfunctioning (delayed activity) and or absence of amylases (4.alpha.D-glucan glucanohydrolase; Exo-1,4.alpha.glucosidase; Beta-fructofuranosidase; Protease (3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase) enzyme activity. The invention also relates to the production of pharmaceutical compositions suitable for such treatment. A preferred variant of the invention relates to use of this enzyme complex having amylolytic, lipolytic, and proteolytic activity, especially salivary, gastric, pancreatic and intestinal enzyme complex such as ,4.alpha.D-glucan glucanohydrolase; Exo-1,4.alpha.glucosidase; Beta-fructofuranosidase; Protease (3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase or digestive enzyme complex containing ,4.alpha.D-glucan glucanohydrolase; Exo- 1,4.alpha.glucosidase; Beta-fructofuranosidase, for the treatment of excess polysaccharides in the body in association with or without malfunctioning, delayed or absent amylases (4.alpha.D-glucan glucanohydrolase; Exo-1,4.alpha.glucosidase; Beta-fructofuranosidase; Protease (3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase) enzyme activity but not deficiency. According to the invention, normal ranges of amylases activity are: 30 to 120 minutes for the degradation of disaccharides by the disaccharides specialised amylases (disaccharides specialised salivary, pancreatic or systemic amylases were not known before), and 4 to 6, up to 8 hours for the degradation of polysaccharides by polysaccharides specialised amylases. Tests results for amylase activity on polysaccharides, and amylase activity on disaccharides is compared to a normal range of 30 to 120 minutes for disaccharides, and 4 to 8 hours for polysaccharides (meaning: 50 to 250 mg/dl of glucose detected in a disaccharide test sample within 30 to 120 minutes, and 55 to 250 mg/dl of glucose to be detected in a polysaccharides sample within 4 to 8 hours). Normal range for disaccharides and polysaccharides are the ranges detected in a healthy non polysaccharides, oligosaccharides, disaccharides and monosaccharides diseases, non diabetic, non diseased individuals in a low endemic diabetes area (normal range figures obtained from healthy subjects in western Sudan and Darfur region where diabetes is approximately 7% of the population). Normal ranges for the tests can also be compared from the following calculations: Glucamylase: 1 unit of enzyme activity catalyzes the production of 1.0mg (1.0ml) of glucose in 1 hour under the following condition: 40 C pH = 4.6, Amylase: 1 unit of enzyme activity is the amount of enzyme that will dextrinize 1.0mg (1.0ml) of soluble starch in 1 hour under the following condition: 60 C pH = 6.0, High temperature amylase: 1 unit of enzyme activity is the amount of enzyme that will dextrinize 1.0mg (1.0ml) of soluble starch in 1 hour under the following condition: 70 C pH = 6Ø
Arbab Tarig S.m.
Miltons Ip/p.i.
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