A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61K 8/66 (2006.01) A61K 38/47 (2006.01) A61Q 19/08 (2006.01) G01N 33/50 (2006.01) G01N 33/66 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2654374
Physiological protein and enzyme complex having active Trimethylglycine, active amylases, active lipases, active proteases, active invertase, active glucoamylase, active lactase, active cellulose, active pectinase, and active malt- diastase of human (saliva enzymes, pancreatic enzymes), yeast, plant, fungi, and or microbial origin, preferably digestive enzyme complex such as, Trimethylglycine, 4-.alpha.-D-glucan glucanohydrolase; Exo-1,4-.alpha.- glucosidase; Beta--fructofuranosidase; Protease (3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase, or digestive enzyme complex containing proteins and enzymes for the treatment of high levels of saccharides and correction of amylases malfunctioning activity or inactivity in the body. The invention also relates to the production of pharmaceutical compositions suitable for such treatment. A preferred variant of the invention relates to use of this enzyme complex having Trimethylglycine, amylolytic, lipolytic, and proteolytic activity, especially salivary, gastric, pancreatic and intestinal enzyme complex for the treatment of malfunctioning, or inactivity of enzymes such as Exo-1,4-.alpha.-glucosidase; Beta--fructofuranosidase; Protease (3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase, and specifically amylases enzymes activity but not deficiency, in association with or without excess saccharides in the body. Normal Ranges for Saliva Amylase activity on Disaccharides (Standard organic, non GM, non resistant, Sucrose reagent) and Saliva Amylase activity on Polysaccharides (Standard organic, non GM, non resistant, polysaccharides starch) tests results According to the invention, normal ranges of amylases activity are: 30 to 120 minutes for the degradation of disaccharides by the disaccharides specialised amylases (disaccharides specialised salivary, pancreatic or systemic amylases were not known before), and 4 to 6, up to 8 hours for the degradation of polysaccharides by polysaccharides specialised amylases. Tests results for amylase activity on polysaccharides, and amylase activity on disaccharides is compared to a normal range of 30 to 120 minutes for disaccharides, and 6 to 8 hours for polysaccharides (meaning: 250 mg/di of glucose detected in a disaccharide test sample within 30 to 120 minutes, and 250 mg/dl of glucose to be detected in a polysaccharides sample within 6 to 8 hours),. Normal range for disaccharides and polysaccharides are the ranges detected in a healthy non polysaccharides, oligosaccharides, disaccharides and monosaccharides diseases, non diabetic, non diseased individuals in a low endemic diabetes area (normal range figures obtained from health subjects in western Sudan and Darfur region where diabetes is approximately 7% of the population). Normal ranges for the tests can also be compared from the following calculations: Glucamylase: 1 unit of enzyme activity catalyzes the production of 1.0mg (1.0ml) of glucose in 1 hour under the following condition: 40 C pH = 4.6, Amylase: 1 unit of erizyme activity is the amount of enzyme that will dextrinize 1.0mg (1.0ml) of soluble starch in 1 hour under the following condition: 60 C pH = 6.0, High temperature amylase: 1 unit of enzyme activity is the amount of enzyme that will dextrinize 1.0mg (1.0ml) of soluble starch in 1 hour under the following condition: 70 C pH = 6Ø
Arbab Tarig S.m.
Na
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