C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/18 (2006.01)
Patent
CA 2363875
The invention relates to a process for obtaining N-(4-trifluoromethylphenyl)-5- methyl- isoxazole-4-carboxamide in crystalline form, which is essentially free of byproducts. For this purpose, N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide is transferred into an organic solvent or into mixtures of organic solvents and water, the amount of byproduct in the solution is determined by quantitative analysis and an equimolar amount of a base is added. N-(4-Trifluoromethylphenyl)-5-methyl- isoxazole-4-carboxamide is isolated from the resulting solution by crystallization.
L'invention concerne un procédé permettant d'obtenir du N-(4-trifluorométhylphényl)-5-méthyl-isoxazole-4-carboxamide sous forme cristalline et sensiblement dépourvu de sous-produits. Pour ce faire, on convertit du N-(4-trifluorométhylphényl)-5-méthyl-isoxazole-4-carboxamide en un solvant organique ou en des mélanges de solvants organiques et d'eau. La quantité de sous-produits est déterminée dans la solution par analyse quantitative et une quantité équimolaire d'une base est ajoutée. A partir de la solution ainsi obtenue, on sépare le N-(4-trifluorométhylphényl)-5-méthyl-isoxazole-4-carboxamide par cristallisation.
Faasch Holger
Gappisch Andreas
Hedtmann Udo
Lau Hans-Hermann
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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