Method for activating regulatory t-cells

Details Method for activating regulatory t-cells Method for activating regulatory t-cells

A - Human Necessities

61

K

A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/513 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2691368

The invention relates to a method for activating regulatory t-cells (Treg- cells) of the human or animal body, comprising a step of bringing into contact the regulatory t-cells (Treg-cells) in a suitable liquid medium with one or a plurality of inhibitors of alanyl-amino peptidase (amino peptidase N; APN) and/or with one or a plurality of inhibitors of peptidases with the same substrate specification by induction of a suppressive effect of the regulatory t-cells (Treg-cells).

La présente invention concerne un procédé d'activation de lymphocytes T régulateurs (Treg) du corps humain ou animal, comprenant une étape de mise en contact des lymphocytes T régulateurs (Treg), contenus dans un milieu liquide approprié, avec un ou plusieurs inhibiteurs de l'alanyl-aminopeptidase (aminopeptidase N; APN) et/ou avec un ou plusieurs inhibiteurs de peptidases présentant les mêmes spécificités du substrat sous induction d'une action suppressive des lymphocytes T régulateurs (Treg).

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