A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/335 (2006.01) A61K 31/34 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/46 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2057973
A-1497-124 Abstract A method for the treatment of anxiety comprising administering to a patient in need of such treatment an anxiolytically effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof Image wherein Z represents the carbon and hydrogen atoms necessary to complete a substituted or unsubstituted, saturated or unsaturated, 5- to 7-membered ring; R1, R2, and R3 may be the same or different and represent a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, lower alkoxy, amino, lower alkyl substituted amino, acylamido, sulfonamido, halogen, and nitro; A represents moiety selected from the group consisting of formulas (II), (III), (IV), (V), (VI) and (VII). Image Image (II) (III) Image Image (IV) (V) A-1497-124 Image Image (VI) (VII) wherein W represents a single bond or the carbon and hydrogen atoms necessary to complete a 3- to 8-membered saturated or unsaturated ring; Y represents a single bond or the carbon and hydrogen atoms necessary to complete a 4 to 8 membered saturated or unsaturated ring; R6 is selected from the group consisting of hydrogen, lower alkyl, phenyl, phenalkyl, fluorine-substituted alkyl, propargyl, and allyl; R6 and R8 may be the same or different and selected from the group consisting of hydrogen, lower alkyl, and lower hydroxyalkyl; M1 and M2 are the same or different and represent hydrogen or methyl; R11 and R12 are the same or different and represent lower alkyl, cycloalkyl, or phenalkyl, and n is 0 or an integer of 1 to 3; provided that when Z represents the atoms necessary to complete a 2,3,4,5-tetrahydro-1-benzoxepin ring, R1 may not equal hydrogen, amino, or alkylamino and R2 may not equal hydrogen or halogen; when Z represents the atoms necessary to complete a 2,2-dimethyl- 2,3-dihydrobenzofuran ring, R1, R2 and R3 may not simultaneously equal hydrogen and when R2 is flourine, R1 and R3 may not equal hydrogen; and when Z represents the atoms necessary to complete a 2,2- dimethyl or a 2,2-diethyl 3,4-dihydrobenzopyran ring, R2 may not equal fluorine or chlorine when R1 and R3 are hydrogen.
Erbamont Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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