A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/455 (2006.01) A61P 17/00 (2006.01) A61K 31/203 (2006.01)
Patent
CA 2679315
The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well.
La présente invention concerne l'utilisation d'alkylesters d'acide nicotinique, notamment de nicotinate de myristyle, afin d'inhiber les effets secondaires associés à un traitement à l'acide rétinoïque. Cette invention concerne également un procédé permettant d'améliorer la différenciation de cellules de peau, lequel procédé consiste à administrer une quantité d'alkylester d'acide nicotinique suffisante pour augmenter l'expression de caspase 14 et de filaggrine. Il est également possible de traiter des déficits d'expression de ces molécules de cette manière.
Coyle Donna L.
Coyle Russell
Jacobson Elaine L.
Jacobson Myron K.
Kim Hyuntae
Arizona Board Of Regents On Behalf Of The University Of Arizona
Goudreau Gage Dubuc
University Of Kentucky Research Foundation
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