Method for amplifying nucleic acid sequences by...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2200627

A target nucleic acid sequence (12) may be amplified in the presence of an enzymatic system including DNA polymerase, strand translocation and RNAse H activities by using a chimeric primer (A1, A2) that includes, in the 5' to 3' direction, an RNA-type segment capable of hybridising with a 3'-terminal segment of the target and a DNA-type segment capable of hybridising with a segment adjacent to said 3'-terminal segment of the target, and a DNA- or RNA-type primer B1 capable of hybridising with said 3'-terminal segment of the target. A cyclic amplification is achieved that may be implemented isothermally on the basis of either a DNA or an RNA target even when the terminals are not defined.

Pour amplifier une séquence d'acide nucléique cible (12), en présence d'un système enzymatique comprenant des activités d'ADN polymérase, de déplacement de brin et de RNAse H, on utilise une amorce chimère (A1, A2) comprenant successivement, dans le sens 5' ? 3', un segment de type ARN capable de s'hybrider avec un segment de l'extrémité 3' de la cible et un segment de type ADN capable de s'hybrider avec un segment contigu audit segment d'extrémité 3' de la cible, et une amorce B1, de type ADN ou ARN, capable de s'hybrider avec ledit segment de l'extrémité 3' de la cible. On obtient une amplification cyclique pouvant être mise en oeuvre de façon isotherme et réalisable indifféremment à partir d'une cible ADN ou ARN, même lorsque les extrémités ne sont pas définies.

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