Method for antigen-specific immunoregulation by t-cell alpha...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 14/725 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2179018

Methods for modulating immune responses in an antigen-specific fashion are disclosed. The methods utilize soluble TCR.alpha. chains which are capable of binding to the antigen, and which, in the presence of an accessory component, suppress the immune response in an antigen-specific manner. The use of TCR.alpha. chains which demonstrate such activity in therapeutic protocols for treating hyperimmune and immunodeficient conditions is described.

Des procédés permettent de moduler des réponses immunitaires de manière spécifique d'un antigène. Ces procédés consistent à utiliser des chaînes .alpha. solubles de récepteurs des lymphocytes T qui peuvent se lier à un tel antigène et qui, en présence d'un composant accessoire, répriment la réponse immunitaire de manière spécifique à un antigène. On décrit l'utilisation des chaînes .alpha. des récepteurs des lymphocytes T qui témoignent d'une telle activité dans des protocoles thérapeutiques destinés à traiter des troubles dus à une hyperimmunité ou à une immunodéficience.

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