G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) A61P 9/00 (2006.01) C07K 14/775 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2449393
The present invention relates to a new method for measuring apolipoprotein CIII ("apo CIII") in apo B and non apo B containing lipoparticles. This invention also relates to synthetic apo CIII products, corresponding antibodies, kits comprising the same, and their use to detect, quantify and/or monitor apo CIII levels in a sample, as well as to quantify and/or monitor atherogenic lipoparticle levels in a sample. The above compounds and kits can also be used to modulate apo CIII levels or activity in vitro or in vivo, and to regulate lipid metabolism in a subject.
L'invention concerne une nouvelle méthode de mesure de l'apolipoprotéine CIII (<= apo CIII >=) dans des lipoparticules contenant apo B et des lipoparticules exemptes de apo B. Par ailleurs, l'invention concerne des produits à base de apo CIII synthétique, des anticorps correspondants, des kits contenant ceux-ci, ainsi que leur utilisation pour détecter, quantifier et/ou contrôler les taux de apo CIII dans un échantillon, et pour quantifier et/ou contrôler les taux de lipoparticules athérogènes dans un échantillon. On peut également utiliser ces composés et ces kits pour moduler les taux de apo CIII ou son activité in vitro ou in vivo, et pour réguler le métabolisme lipidique d'un sujet.
Majd Zouher
Najib-Fruchart Jamila
Genfit
Robic
LandOfFree
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