Method for assaying for substances which affect bcr-abl...

Details Method for assaying for substances which affect bcr-abl... Method for assaying for substances which affect bcr-abl...

G - Physics

01

N

G01N 33/573 (2006.01) A61K 38/17 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2113494

ABSTRACT OF THE DISCLOSURE A method for assaying for a substance that affects BCR-ABL mediated transformation which comprises reacting the substance with a first compound containing Grb2, or a portion thereof, and a second compound containing a Grb2 binding site on BCR-ABL, Sos or Shc under conditions where the first and second compounds are capable of forming a complex, and comparing with a control. The invention also relates to a method of using the substance to regulate BCR-ABL mediated transformation; and a pharmaceutical composition comprising a compound containing Grb2 or a portion thereof, the Grb2 binding site on BCR-ABL, Sos or Shc, or mimetics thereof, and a pharmaceutically acceptable carrier. Methods of treating patients suffering from CML or ALL are also contemplated.

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