G - Physics – 06 – G
Patent
G - Physics
06
G
G06G 7/48 (2006.01) C12P 19/34 (2006.01) C12P 21/06 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2441060
The present invention provides methods for identifying relationships between gene expression and protein modifications in a cell by determining gene expression generated in the cell, determining protein modifications generated in the cell, and coordinating the gene expression and protein modifications generated in the cell. Also provided by the present invention is a computer system for identifying such a relationship between gene expression and protein modifications. The present inventive methods and computer systems are useful for investigating a variety of physiological or pathophysiological processes, including metabolic pathways, typing of diseased cells, and identifying biological activities of test materials.
L'invention concerne des procédés d'identification de relations entre une expression génique et des modifications protéiques dans une cellule, par détermination d'une expression génique générée dans la cellule, par détermination de modifications protéiques générées dans la cellule et par coordination de l'expression génique et des modifications protéiques générées dans la cellule. L'invention concerne également un système informatique permettant d'identifier une telle relation entre une expression génique et des modifications protéiques. Les procédés et systèmes informatiques selon l'invention sont utiles pour la recherche d'une palette de processus physiologiques ou pathophysiologiques, notamment des voies métaboliques, pour la détermination des types de cellules malades et pour l'identification des activités biologiques des substances d'essai.
Babish John G.
Hatzis Christos
Pacioretty Linda M.
Prakash Pankaj
Ashni Naturaceuticals Inc.
Babish John G.
Blake Cassels & Graydon Llp
Hatzis Christos
Pacioretty Linda M.
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