Method for augmenting b cell depletion

Details Method for augmenting b cell depletion Method for augmenting b cell depletion

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/015 (2006.01) A61K 31/12 (2006.01) A61K 31/16 (2006.01) A61K 31/216 (2006.01) A61K 31/33 (2006.01) A61K 31/395 (2006.01) A61K 38/06 (2006.01) A61P 37/00 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2563432

The present invention provides methods of augmenting B cell depletion by promoting intravascular access of B cell subsets sequestered in lymphoid tissues rendering the B cells sensitive to killing mediated by the B cell depleting agent. One method of promoting intravascular access is by the use of integrin antagonists. Methods of treating B cell disorders by this approach is also provided.

L'invention concerne des méthodes permettant d'augmenter l'appauvrissement des lymphocytes B en stimulant l'accès intravasculaire de sous-ensembles de lymphocytes B séquestrés dans les tissus lymphoïdes rendant ainsi les lymphocytes B susceptibles d'être tués par l'agent d'appauvrissement des lymphocytes B. Une méthode de stimulation de l'accès intravasculaire consiste à utiliser des antagonistes de l'intégrine. L'invention concerne également des méthodes permettant de traiter les troubles des lymphocytes B au moyen de cette approche.

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