A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/727 (2006.01)
Patent
CA 2694189
A method and medicament is provided for treating and inhibiting interaction of the receptor for advanced glycation end-products (RAGE) and its ligands using a natural or synthetic sulfated polysaccharide, preferably a 2-0 desulfated heparin. The medicament preferably is administered intravenously, by aerosolization, intra-nasally, intra-articularly, intra-thecally, subcutaneously, topically or orally. The medicament is useful for treating a variety of conditions, including diabetes, inflammation, renal failure, aging, systemic amyloidosis, Alzheimer's disease, inflammatory arthritis, atherosclerosis, and colitis.
L'invention concerne un procédé et un médicament pour traiter et inhiber une interaction du récepteur des produits finaux de glycation avancée (RAGE) et ses ligands en utilisant un polysaccharide sulfaté naturel ou synthétique, de préférence une héparine désulfatée 2-0. Le médicament est de préférence administré de manière intraveineuse, par nébulisation, de manière intranasale, intra-articulaire, intrathécale, sous-cutanée, topique ou orale. Le médicament est utile pour traiter une série d'états, y compris des diabètes, l'inflammation, l'insuffisance rénale, le vieillissement, l'amylose systémique, la maladie d'Alzheimer, l'arthrite inflammatoire, l'athérosclérose, et la colite.
Ridout & Maybee Llp
University Of Utah Research Foundation
LandOfFree
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