A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01) A61K 31/665 (2006.01) A61K 31/67 (2006.01) A61K 31/675 (2006.01)
Patent
CA 2080158
Abstract METHOD FOR BLOCKING NEOPLASTIC TRANSFORMATION OF CELLS INDUCED BY RAS ONCOGENES EMPLOYING BISPHOSPHONATE COMPOUNDS OR ANALOGS THEREOF A method is provided by blocking or preventing the prenylation of CAAX box containing proteins including ras oncogene products thereby preventing and/or treating ras-related tumors which includes the step of administering a therapeutically effective amount of a protein-prenyl transferase inhibitor which is a bisphosphonate or analog thereof.
Barbacid Mariano
Biller Scott A.
Gordon Eric M.
Magnin David R.
Manne Veeraswamy
Barbacid Mariano
Biller Scott A.
Gordon Eric M.
Magnin David R.
Manne Veeraswamy
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