Method for blocking platelet adhesion to collagen

Details Method for blocking platelet adhesion to collagen Method for blocking platelet adhesion to collagen

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/16 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2055146

30/RSP17 18209IA TITLE OF THE INVENTION A MFTHOD FOR BLOCKING PLATELET ADHESION TO COLLAGEN ABSTRACT OF THE DISCLOSURE A method for blocking platelet adhesion to collagen by contacting platelets with a polypeptide having one of the following sequences: NH2 (Ch) Ala Arg Gly Asp (Cx) COOH (i) NH2 (Ch) Ala Ala Gly Asp (Cx) COOH (ii) NH2 (Ch) Ala Arg Tyr Asp (Cx) COOH (iii) NH2 (Ch) Ala Arg Gly Asp (Cy) Z (iv) wherein Ch, Cx, Cy are defined amino acid sequences or conservatively substituted amino acid sequences, and Z is NH2 or COOH.

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