Method for cell adhesion and wound healing

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2409506

The present invention relates to a method for cell adhesion and wound healing with internal domains of .beta.ig-h3. Particularly, the present invention relates to the method of using recombinant proteins containing one or more of 2nd or 4th internal domain of .beta.ig-h3 for cell adhesion and wound healing, wherein the 2nd or 4th internal domain of .beta.ig-h3 has aspartic acid and isoleucine essential for interaction with integrin which represent a high homology in base sequence of .beta.ig-h3 internal domains. The recombinant proteins containing one or more 2nd or 4th internal domain of .beta.ig-h3 are effective for cell adhesion and wound healing by itself and can be used for developing cell culture medium and wound healing agent.

L'invention concerne un procédé d'adhérence cellulaire et de guérison de blessure portant sur les domaines internes de .beta.ig-h3. Elle concerne particulièrement, un procédé d'utilisation de protéines de recombinaison comprenant un ou plusieurs du deuxième ou du quatrième domaine interne de .beta.ig-h3 d'adhérence cellulaire et de guérison de blessure, ce deuxième ou ce quatrième domaines internes de .beta.ig-h3 possédant acide aspartique et isoleucine jouant un rôle essentiel interactif avec intégrine représentant une forte homologie dans la séquence de base des domaines internes .beta.ig-h3. Ces protéines de recombinaison comprenant un ou plusieurs deuxièmes ou quatrièmes domaines internes de .beta.ig-h3 sont efficaces pour l'adhérence cellulaire et la guérison des blessures par elles-mêmes et on peut les utiliser afin de créer un milieu de culture de cellules et un agent de guérison de blessure.

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