G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2600206
The method for qualitative and quantitative detecting of the extend of use and the correct process flow of the mammalian aerobic glucose fermentation metabolic pathway (mam-aGF) in a mammalian individual is characterized in that the enzyme TKTLl is used as indicator and target molecule and that the structural and/or functional parameter of said TKTLl in a biological sample of said individual (patient) are taken as indication for the qualitative and quantitative run of the mam-aGF in the cells and/or tissue of said individual (patient). In combination with the use of inhibitors and activators of that mam-aGF the method is further suitable for checking and controlling the mam- aGF in an individual (patient).
L'invention concerne un procédé de détection qualitative et quantitative de l'étendue d'utilisation et du bon fonctionnement du trajet métabolique de fermentation de glucose aérobie mammifère (mam-aGF) chez un individu mammifère, caractérisé en ce que l'enzyme TKTLl sert d'indicateur et de molécule cible et en ce que le paramètre structurel et/ou fonctionnel de ladite enzyme TKTLl dans un échantillon biologique dudit individu (patient) sert d'indication du déroulement qualitatif et quantitatif de la fermentation mam-aGF dans les cellules et/ou le tissu dudit individu (patient). En combinaison avec l'utilisation d'inhibiteurs et d'activateurs de cette fermentation mam-aGF, le procédé convient par ailleurs au contrôle et à la régulation de la fermentation mam-aGF chez un individu (patient).
Borden Ladner Gervais Llp
Coy Johannes
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