C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/20 (2006.01) C07C 303/40 (2006.01) C07C 311/19 (2006.01)
Patent
CA 2583771
The invention relates to a method for cleaning 3-hydroxyamidinophenylalanine derivatives comprising the steps: (a) addition of an aromatic sulphonic acid to a solution of an optionally contaminated 3-hydroxyamidinophenylalanine derivative in order to form a precipitate; (b) separation of the precipitate formed in step (a); and (c) recovery of the free 3-hydroxyamidinophenylalanine derivative from the precipitate. 3-hydroxyamidinophenylalanine derivatives can e.g. be used as urokinase inhibitors. The invention also relates to the use of highly pure 3-hydroxyamidinophenylalanine derivatives for producing 3- amidinophenylalanine derivatives.
L'invention concerne un procédé servant à purifier des dérivés de 3-hydroxy-amidinophénylalanine et comprenant les étapes suivantes : (a) ajout d'un acide sulfonique aromatique à une solution contenant un dérivé de 3-hydroxy-amidinophénylalanine éventuellement impur afin de former un précipité ; (b) séparation du précipité obtenu à l'étape (a) ; (c) récupération du dérivé de 3-hydroxy-amidinophénylalanine libre à partir du précipité. Les dérivés de 3-hydroxy-amidinophénylalanine peuvent, par exemple, être utilisés en tant qu'inhibiteurs de l'urokinase. L'invention concerne également l'utilisation de dérivés de 3-hydroxy-amidinophénylalanine de grande pureté pour produire des dérivés de 3-amidinophénylalanine.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Wilex Ag
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