Method for cleaving cervimycin monoesters

Details Method for cleaving cervimycin monoesters Method for cleaving cervimycin monoesters

C - Chemistry, Metallurgy

12

P

C12P 19/56 (2006.01)

Patent

CA 2628838

The invention relates to a method for cleaving cervimycin monoesters. The object of the invention, of converting in a simple manner the cervimycin esters which are less active but are formed in larger quantity into the highly active cervimycin K which occurs as a minor component in the preparation by fermentation, is achieved by preparing unesterified cervimycins from cervimycin esters with di- or monomethylated malonic acids, where at least one esterolytic enzyme acts on the cervimycin malonic esters at temperatures from 20~C to 75~C, preferably from 40 to 76~C, at a pH of pH 5.0 to 10.0, preferably pH 6.0 to 9.0, for a time of from 0.1 h to 48 hours.

L~invention concerne un procédé de clivage de semi-esters de cervimycine. L~invention a pour objet la conversion, par une méthode simple, d'un ester de cervimycine faiblement actif mais formé en grande quantité en cervimycine K, obtenue en tant que composant minoritaire par fermentation, ladite conversion étant réalisée en fabriquant de la cervimycine non estérifiée à partir d~esters de cervimycine avec des acides maloniques diméthylés ou monométhylés, au moins une enzyme estérolytique agissant sur l~ester de l~acide malonique-cervimycine pendant une durée comprise entre 0,1 heures et 48 heures, à une température comprise entre 20 °C et 75 °C, de préférence entre 40 et 76 °C, à un pH compris entre 5,0 et 10,0, de préférence entre 6,0 et 9,0.

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