C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 31/517 (2006.01) A61K 31/549 (2006.01) A61K 38/48 (2006.01) A61P 9/10 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C07K 14/61 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2441503
The invention relates to a method for cleaving human growth hormone GH, by means of matrix metalloproteinase MMP. It has been found that MMP-3 cleaves the hormone into two fragments, of which the 16kDa fragment is stable. The invention provides means which positively influence tumour growth, proliferative diabetic retinopathy and also angiogenesis, in particular on treatment of coronary infarct, retarded wound healing, menstrual cycle disturbances and others, by means of regulation of the human growth hormone.
L'invention concerne un procédé de dissociation de l'hormone de croissance humaine (HGH) par une métalloprotéase matricielle. Il a été démontré que la MMP-3 dissocie l'hormone de croissance en deux fragments, parmi lesquels le fragment 16kDa est stable. L'objectif de cette invention est de produire des agents qui, en régulant l'hormone de croissance humaine et la croissance tumorale, influencent de façon positive la rétinophatie diabétique proliférative ainsi que l'angiogénèse, notamment dans le traitement de l'infarctus cardiaque, de la cicatrisation retardée de plaies, de troubles du cycle menstruel et analogues.
Arkona Christoph
Hermann Konrad
Arkona Christoph
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hermann Konrad
Ibfb Gmbh Privates Institut Fuer Biomedizinische Forschung Und B
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