C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/805 (2006.01) C07K 1/107 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2236794
The present invention relates to cross-linked hemoglobins, and particularly to methods of controlling the functionality of such hemoglobins. The controlled functionalities include the P50 and the Hill coefficient. The present invention provides methods for producing a cross-linked hemoglobin with specific final functionalities by regulating the amount of both total hemoglobin and R-state hemoglobin prior to cross-linking, and by modulating cross-linking reaction conditions such as time, temperature, pH and the ratio of cross-linking reagent to hemoglobin.
L'invention concerne des hémoglobines réticulées, et particulièrement des procédés de régulation de la fonctionnalité de ces hémoglobines. Les fonctionnalités régulées sont notamment le P¿50? et le coefficient de Hill. Sont décrites des méthodes permettant d'obtenir une hémoglobine réticulée avec des fonctionnalités finales spécifiques par la régulation de la quantité de l'hémoglobine totale et de l'hémoglobine à l'état R avant la réticulation, et la modulation des conditions de réaction de réticulation telles que le temps, la température, le pH et la proportion de réactif de réticulation par rapport à l'hémoglobine.
Kerwin Bruce A.
Smart & Biggar
Somatogen Inc.
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