Method for controlled polymerization of o-carboxy anhydrides...

C - Chemistry – Metallurgy – 08 – G

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C08G 63/08 (2006.01)

Patent

CA 2582419

The invention concerns a method for preparing poly(-hydroxy acids), the polymerization reaction being performed in controlled manner in the presence of a catalytic system including a base, said base being a 5- or 6-membered aromatic heterocycle comprising at least one endocyclic nitrogen atom, provided that when the base is used alone in the catalytic system, it does not represent pyridine, 2-methylpyridine, 2,6-dimethylpyridine or 2-methoxypyridine. The invention also concerns poly(-hydroxy acids) of formula (IV). Finally, the invention concerns the use of a poly(-hydroxy acid), obtainable by the inventive method, for vectoring active principles or for making biomaterials.

La présente invention concerne un procédé de préparation de poly(-hydroxy acides), la réaction de polymérisation étant réalisée de manière contrôlée en présence d'un système catalytique comprenant une base, ladite base étant un hétérocycle aromatique à 5 ou 6 chaînons comprenant au moins un atome d'azote endocyclique, sous réserve que lorsque la base est utilisée seule dans le système catalytique, elle ne représente pas la pyridine, la 2-méthylpyridine, la 2,6-diméthylpyridine ou la 2-méthoxypyridine. La présente invention concerne aussi des poly(-hydroxy acide) de formule (IV): La présente invention concerne enfin l'utilisation d'un poly(-hydroxy acide), susceptible d'être obtenu par le procédé décrit, pour la vectorisation de principes actifs ou pour la fabrication de biomatériaux.

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