Method for controlled production of ultrafine microparticles...

Details Method for controlled production of ultrafine microparticles... Method for controlled production of ultrafine microparticles...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/51 (2006.01) C08J 3/12 (2006.01)

Patent

CA 2375992

The invention concerns ultrafine microparticles and nanoparticles, and a method for controlled production thereof in the absence of or with minimum water, in the absence of plasticizers or under reduced temperature constraint. The method is characterised in that it consists in subjecting a matrix material to a high pressure homogenising process in an anhydrous or dry or low temperature medium, preferably at room temperature (20~C) and in particular below the freezing point of water. Said process brings about controlled fine grinding and reduces to a minimum the damaging influence of the chemical stability of the homogenised material.

L'invention concerne des microparticules et des nanoparticules extra-fines, ainsi qu'un procédé pour les produire avec ménagement en l'absence d'eau ou avec un minimum d'eau, en l'absence de plastifiants ou sous contrainte de température réduite. Dans le procédé selon l'invention, on soumet un matériau matriciel à un processus d'homogénéisation haute pression dans un milieu anhydre ou sec ou à basse température, de préférence à température ambiante (20 ·C) et en particulier en dessous du point de congélation de l'eau. Ce processus provoque une pulvérisation douce des particules et minimise l'influence néfaste de la stabilité chimique du matériau homogénéisé.

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