Method for controlling angiogenesis in animals

Details Method for controlling angiogenesis in animals Method for controlling angiogenesis in animals

C - Chemistry, Metallurgy

08

B

C08B 37/06 (2006.01) A61K 31/00 (2006.01) A61K 31/715 (2006.01) A61K 31/732 (2006.01)

Patent

CA 2467451

Disease conditions which are dependent upon or moderated by angiogenesis are controlled by the use of a therapeutic material which interacts with cell surface galectins. Particular therapeutic materials comprise a polymeric backbone having side chains terminating in a sugar dependent therefrom. Disclosed are specific therapeutic materials in which the polymeric backbone is based upon polygalacturonic acid, and the side chains terminate in arabinose or galactose.

L'utilisation d'un matériau thérapeutique interagissant avec les galectines de surface cellulaire permet de lutter contre les états pathologiques dépendants de l'angiogenèse ou modérés par cette dernière. Certains matériaux thérapeutiques comprennent un squelette polymère possédant des chaînes latérales dépendantes de ce dernier et se terminant en un sucre. L'invention concerne des matériaux thérapeutiques particuliers, dont le squelette polymère est à base d'acide polygalacturonique, et dont les chaînes latérales se terminent en arabinose ou en galactose.

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