Method for controlling glucose uptake and insulin sensitivity

Details Method for controlling glucose uptake and insulin sensitivity Method for controlling glucose uptake and insulin sensitivity

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 5/50 (2006.01)

Patent

CA 2684254

The invention provides methods for treating diabetes and related disorders, such as metabolic syndromes (which includes insulin resistance), by administering an inhibitor of osteopontin (OPN), which includes an antibody, antibody fragment, siRNA, and aptamer. Also disclosed are methods for increasing glucose uptake by cells in a subject, by administering an inhibitor of OPN.

L'invention propose des procédés pour traiter le diabète et des troubles associés, tels que des syndromes métaboliques (qui comprennent la résistance à l'insuline), par l'administration d'un inhibiteur de l'ostéopontine (OPN) qui comprend un anticorps, un fragment d'anticorps, un ARNsi et un aptamère. Des procédés pour augmenter la prise de glucose par des cellules chez un sujet, par l'administration d'un inhibiteur d'OPN, sont également décrits.

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