Method for controlling liposome size

Details Method for controlling liposome size Method for controlling liposome size

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2361551

A method of preparing liposomes to a selected particle size is described. In the method, a vesicle-forming lipid dissolved in a lipid solvent is hydrated with a second solvent to form a hydration mixture having greater than 10 and less than 50 weight percent of the lipid solvent. The target amount of lipid solvent in the lipid solvent is selected to obtain a desired particle size.

Procédé servant à préparer des liposomes dont les particules présentent une dimension sélectionnée. Ce procédé consiste à hydrater un lipide formant une vésicule et dissous dans un solvant lipidique avec un deuxième solvant, de manière à obtenir un mélange d'hydratation supérieur à 10 % en poids et inférieur à 50 % en poids du solvant lipidique. On sélectionne la quantité ciblée de solvant lipidique dans le solvant lipidique afin d'obtenir la dimension souhaitée de particules.

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