C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/10 (2006.01) A61K 31/727 (2006.01) C08B 37/00 (2006.01)
Patent
CA 2198908
Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated up to about 99 % and 75 % desulfated at the 2-O and 3-O positions, respectively.
Il s'agit de méthodes destinées à produire et à utiliser des compositions d'héparine O-désulfatées, de préférence des compositions d'héparine 2-O et 3-O désulfatées, comme agents prophylactiques ou thérapeutiques pour la prévention ou le traitement de certaines maladies, y compris le cancer. Ces méthodes permettent de réguler le degré de 2-O et 3-O de désulfatation afin de produire des compositions qui sont désulfatées de manière variable, dans des proportions allant de, respectivement, 99 et 75 % de désulfatation aux positions 2-O et 3-O.
Holme Kevin R.
Liang Weisheng
Shaklee Patrick N.
Tyrrell David J.
Glycomed Incorporated
Smart & Biggar
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