C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/113
C12P 17/18 (2006.01) C12R 1/645 (1980.01)
Patent
CA 1168606
ABSTRACT OF THE DISCLOSURE The invention relates to a new method for controlling the level and distribution of alkaloids produced by Claviceps purpurea variant strains capable of producing primarily ergo- cornine, .alpha.-ergocryptine and .beta.-ergocryptine under saprophytic conditions. According to the invention a compound of the bio- synthesis path of isopleucine or a compound which promotes the formation of isoleucine by biochemical control is added to the fermentation broth. In other respects fermentation is performed under conditions known per se. By the method of the invention the ratio of .alpha.- and .beta.-ergocryptine formed in the fermentation broth can be ad- justed to the optimum value.
370247
Budai Miklos
Fekete Gyorgy
Gorog Sandor
Herenyi Bulcsu
Nagy Eva U.
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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