Method for convection enhanced delivery of therapeutic agents

Details Method for convection enhanced delivery of therapeutic agents Method for convection enhanced delivery of therapeutic agents

A - Human Necessities

61

B

A61B 5/055 (2006.01) A61K 49/04 (2006.01) A61K 49/08 (2006.01) A61K 49/12 (2006.01) A61K 49/14 (2006.01)

Patent

CA 2499573

A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infused with the therapeutic agent and used to monitor the distribution of the therapeutic agent as it moves through the target tissue. The images obtained during delivery are used to confirm delivery of the therapeutic agent to the target tissue and to avoid exposure of tissue outside of the targeted area to the therapeutic agent. In addition, the signal intensity of the images may be used to confirm that the therapeutic agent has been delivered to the target tissue at a desired concentration.

L'invention concerne un procédé de suivi et de commande d'administration améliorée par convection d'un agent thérapeutique dans un tissu cible. Un traceur détectable, par exemple par imagerie par résonance magnétique (IRM) et/ou par tomographie de rayons X informatisée (CT), est perfusé en même temps que l'agent thérapeutique et utilisé afin de suivre la distribution de l'agent thérapeutique dans son déplacement dans le tissu cible. Les images obtenues lors de l'administration sont utilisées afin de confirmer la délivrance de l'agent thérapeutique dans le tissu cible et d'éviter que les tissus à l'extérieur de la zone ciblée soient exposés à l'agent thérapeutique. En outre, l'intensité du signal des images peut être utilisée afin de confirmer que l'agent thérapeutique a bien été délivré dans le tissu cible avec la concentration recherchée.

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