Method for counteracting a pathologic change in the...

A - Human Necessities – 61 – K

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A61K 31/506 (2006.01) A61K 31/435 (2006.01) A61K 31/4439 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2506978

The invention concerns methods for modulating the .szlig.-adrenergic pathway. In particular, the invention concerns methods for counteracting a pathologic change, such as, for example, a loss in .szlig.-adrenergic sensitivity, in the .szlig.-adrenergic signal transduction pathway by administering an effective amount of a compound capable of inhibiting TGF-.szlig. signaling through a TGF- .szlig. receptor.

L'invention concerne des méthodes permettant de moduler la voie .szlig.-adrénergique, et en particulier des méthodes qui permettent de contrer un changement pathologique, par exemple une perte de la sensibilité .szlig.-adrénergique, dans la voie de transduction du signal .szlig.-adrénergique, par l'administration d'une dose efficace d'un composé capable d'inhiber la signalisation TGF-.szlig. via un récepteur de TGF-.szlig..

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