C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/15.06, 204/9
C07K 14/46 (2006.01) A61L 24/10 (2006.01) A61L 27/24 (2006.01) C08H 1/06 (2006.01) G03F 7/038 (2006.01) A61F 2/00 (2006.01)
Patent
CA 1339516
A method of molecularly crosslinking amino acid-containing polymers through use of a heterobifunctional cross-linking agent. The crosslinking agent includes at least two functional moieties, the first exhibiting conventional, nucleophilic reactivity, while the second is photochemically labile. The crosslinking agent is first reacted at the conventional site with amino acid-containing polymers to form a peptide-like bond. The product is then subjected to photochemical activation whereby the photochemically labile moiety is converted to a reactive intermediate which bonds to an amino acid side chain of either molecules of tissue collagen and/or amino acid-containing polymers in the preparation. Collagen crosslinked by this method can be used as a bioadhesive for sutureless closure of the skin and eye or as a superhydrated material for contact lenses, moist bandage contact lens, lens or corneal implant material, or as a drug delivery mechanism.
591108
Gorin Michael
Kenney Cristina
Maguen Ezra
Martinez Marvin
Nesburn Anthony Bart
Cedars-Sinai Medical Center
Mccarthy Tetrault Llp
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