C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/075 (2006.01) C07K 1/14 (2006.01) C07K 5/072 (2006.01)
Patent
CA 2081869
A method of crystallizing ~-L-aspartyl-L- phenylalanine methyl ester comprises cooling a crystal- lizing solution of ~-L-aspartyl-L-phenylalanine methyl ester by indirect heat exchange with a coolant, the crystallizing solution of ~-L-aspartyl-L-phenylalanine methyl ester having a temperature no more than 20°C higher than the temperature of the coolant, stirring the crystallizing solution of ~-L-aspartyl-L-phenylalanine methyl ester and circulating the coolant while continu- ously feeding an aqueous solution of ~-L-aspartyl-L- phenylalanine methyl ester to the crystallizing solution of ~-L-aspartyl-L-phenylalanine methyl ester. The method of the invention enables one to reduce the amount of scale deposited on heat transfer surfaces of crystallizers.
Abe Sou
Kishimoto Shinichi
Abe Sou
Ajinomoto Co. Inc.
Kishimoto Shinichi
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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