Method for crystallization of a weakly acidic and/or weakly...

Details Method for crystallization of a weakly acidic and/or weakly... Method for crystallization of a weakly acidic and/or weakly...

B - Operations, Transporting

01

D

B01D 9/02 (2006.01)

Patent

CA 2551485

A method for crystallization of a weakly acidic and/or weakly basic compound having an uncharged form and at least one charged form comprises the steps of: a) providing a solution of said compound in a solvent having an initial pH- value and an initial total concentration of said compound, said initial pH- value being chosen such that the compound is present in said solution pre- dominantly in said charged form, said initial total concentration being cho- sen larger than the intrinsic solubility of said uncharged form; b) gradually changing the pH-value of said solution in a direction that leads to a decrease of said compound's solubility until reaching a predetermined target pH-value at which said solution is in a substantially saturated state and the concentration of said uncharged form is substantially equal to said intrinsic solubility thereof; and c) maintaining said solution in a substantially saturated state while allowing formation of crystals of said compound.

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