Method for cultivation of hair follicular dermal sheath cells

Details Method for cultivation of hair follicular dermal sheath cells Method for cultivation of hair follicular dermal sheath cells

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01)

Patent

CA 2624424

Disclosed is a method for cultivation of a hair follicular dermal sheath cell or a precursor cell thereof which is a potential cellular material for hair regeneration by cell transplantation. The method comprises the step of cultivating a hair follicular dermal sheath cell or a precursor cell thereof in an animal cell culture medium supplemented with a platelet-derived growth factor AA (PDGF-AA) and a fibroblast growth factor 2 (FGF2). As a result, the hair follicular dermal sheath cell can be proliferated while maintaining its functions, or the precursor cell can be differentiated into a hair follicular dermal sheath cell and proliferated.

La présente invention concerne un procédé de culture de cellules de la cuticule (Dermal Sheath ; DS) d'un follicule pileux ou de leurs cellules précurseurs, ces cellules pouvant être utilisées pour la régénération capillaire par transplantation de cellules. Le procédé comprend une étape de culture de cellules de la cuticule d'un follicule pileux ou de leurs cellules précurseurs dans un milieu de culture de cellules animales complété par le facteur de croissance dérivé des plaquettes AA (Platelet-Derived Growth Factor AA ; PDGF-AA) et le facteur de croissance des fibroblastes 2 (Fibroblast Growth Factor 2 ; FGF2). Ceci permet aux cellules de la cuticule d'un follicule pileux de proliférer tout en conservant leurs fonctions, ou aux cellules précurseurs de se différencier en cellules de la cuticule d'un follicule pileux et de proliférer.

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