C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/135, 195/128
C12P 21/00 (2006.01) A61K 39/10 (2006.01) C07K 14/235 (2006.01) C12N 1/20 (2006.01) C12N 1/22 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1337859
There is disclosed a method for culturing Bordetella Pertussis in the presence of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising pertussis toxin and filamentous hemagglutinin in a large amount at low cost. From the antigen, there can be obtained a stable and effective pertussis toxoid to be used for a pertussis vaccine. There is also disclosed a vaccine comprising the pertussis toxoid as an active ingredient and a gelatin and/or gelatin derivatives as a stabilizing agent. The present vaccine is extremely stable and can be stored for a prolonged period of time.
541661
Chazono Masashi
Konobe Takeo
Osame Juichiro
Takaku Keisuke
Yoshida Iwao
Ridout & Maybee Llp
The Research Foundation For Microbial Diseases Of Osaka Universi
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