Method for delivering nucleic acids into cells

Details Method for delivering nucleic acids into cells Method for delivering nucleic acids into cells

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) C07J 9/00 (2006.01) C07J 41/00 (2006.01) C12N 15/64 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2116676

2116676 9305162 PCTABS00020 A method for facilitating the transfer of nucleic acids into cells comprising preparing a mixed lipid dispersion of a cationic lipid with a co-lipid in a suitable carrier solvent. The lipid has a structure which includes a lipophilic group derived from cholesterol, a linker bond, a spacer arm including from about 1 to about 20 carbon atoms in a branched or unbranched linear alkyl chain, and a cationic amino group selected from the group consisting of primary, secondary, tertiary and quaternary amino groups. The method further comprises adding the nucleic acids to the dispersion to form a complex. The cells are then treated with the complex. There is also disclosed a novel cationic amphiphile useful for this purpose.

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